Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | PGK2 | P07205 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19507024 | 0.79 | MEN1 (0.38) | RAPGEF4PGK1PGK2MEN1KMT2A | |
| SCHEMBL22808889 | 0.79 | RAPGEF4 (0.43) | RAPGEF4PGK1PGK2NR3C1NR3C2 | |
| SCHEMBL902818 | 0.77 | RAPGEF4 (0.58) | RAPGEF4PGK1PGK2 | |
| SCHEMBL25112321 | 0.77 | TSHR (0.46) | PGK1PGK2 | |
| SCHEMBL19265367 | 0.76 | RAPGEF4 (0.41) | RAPGEF4PGK1PGK2NR3C1NR3C2 | |
| SCHEMBL8826911 | 0.74 | POLB (0.41) | RAPGEF4MEN1KMT2A | |
| SCHEMBL24355295 | 0.74 | PTPN1 (0.38) | PGK1PGK2NR3C1NR3C2PDK2 | |
| SCHEMBL24355315 | 0.73 | AR (0.33) | PGK1PGK2PDK2PDK1PDK3 | |
| SCHEMBL16579376 | 0.71 | RAPGEF4 (0.40) | RAPGEF4 | |
| SCHEMBL22783306 | 0.71 | RAPGEF4 (0.40) | RAPGEF4PGK1PGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022083657-A1 | SUBSTITUTED BENZO OR PYRIDOPYRIMIDINE AMINE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-04-28 | — | — | WO | disclosed |