Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.41 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25767125 | 0.84 | PGK1 (0.40) | RAPGEF4PGK1PGK2PDE2A | |
| SCHEMBL22808889 | 0.83 | RAPGEF4 (0.43) | RAPGEF4PGK1PGK2NR3C1NR3C2 | |
| SCHEMBL902818 | 0.80 | RAPGEF4 (0.58) | RAPGEF4PGK1PGK2 | |
| SCHEMBL16261286 | 0.78 | GABRA1 (0.41) | RAPGEF4PGK1PGK2PDE2A | |
| SCHEMBL8826911 | 0.78 | POLB (0.41) | RAPGEF4 | |
| SCHEMBL15459372 | 0.78 | PDE2A (0.32) | RAPGEF4PDE2A | |
| SCHEMBL24355332 | 0.76 | RAPGEF4 (0.39) | RAPGEF4PGK1PGK2NR3C1NR3C2 | |
| SCHEMBL16579376 | 0.74 | RAPGEF4 (0.40) | RAPGEF4PDE2A | |
| SCHEMBL19507024 | 0.74 | MEN1 (0.38) | RAPGEF4PGK1PGK2NR3C1NR3C2 | |
| SCHEMBL22783306 | 0.73 | RAPGEF4 (0.40) | RAPGEF4PGK1PGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875021-B1 | BETA AMINO ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | UNIV SAINT LOUIS (US) | 2017-08-23 | — | — | EP | disclosed |