Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.51 |
| ▸ | MAP2K4 | P45985 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.48 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 7/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15312372 | 0.78 | MAP2K4 (0.51) | MAP2K4MAPK1MAPK6MAPKAPK3MAPKAPK2 | |
| SCHEMBL2662677 | 0.76 | TRPA1 (0.56) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL5637837 | 0.75 | MAP2K4 (0.44) | TRPA1MAP2K4GSK3B | |
| SCHEMBL24358756 | 0.75 | PDPK1 (0.58) | GSK3BMETAP2 | |
| SCHEMBL15312579 | 0.75 | ITK (0.46) | MAP2K4MAPK1MAPK6MAPKAPK5KIF11 | |
| SCHEMBL13122227 | 0.75 | TRPA1 (0.55) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL30481233 | 0.75 | TRPA1 (0.55) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL25279396 | 0.75 | TRPA1 (0.55) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL30586177 | 0.75 | TRPA1 (0.55) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL1513093 | 0.75 | TRPA1 (0.55) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127254-A1 | INDAZOLYL-ISOXAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127254-A1 | INDAZOLYL-ISOXAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | KIT, TNNI3K, CILK1 | TRPA1 4655/4885MAP2K4 566/4885MAPK1 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.