Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24359351 | 0.92 | NOS1 (0.50) | MAPTRXFP1NOS1HDAC1HDAC2 | |
| SCHEMBL24359483 | 0.92 | NOS1 (0.53) | MAPTRXFP1NOS1HDAC1HDAC2 | |
| SCHEMBL24359381 | 0.84 | PAM (0.54) | MAPTRXFP1NOS1HDAC1HDAC2 | |
| SCHEMBL2627816 | 0.83 | MAPT (0.74) | MAPTRXFP1HDAC1HDAC2HDAC3 | |
| SCHEMBL5981360 | 0.83 | MAPT (0.74) | MAPTRXFP1HDAC1HDAC2HDAC3 | |
| SCHEMBL1327206 | 0.83 | MAPT (0.74) | MAPTRXFP1HDAC1HDAC2HDAC3 | |
| SCHEMBL1285525 | 0.83 | MAPT (0.74) | MAPTRXFP1HDAC1HDAC2HDAC3 | |
| SCHEMBL1404165 | 0.83 | MAPT (0.74) | MAPTRXFP1HDAC1HDAC2HDAC3 | |
| SCHEMBL21359026 | 0.83 | MAPT (0.74) | MAPTRXFP1HDAC1HDAC2HDAC3 | |
| SCHEMBL1326081 | 0.83 | MAPT (0.74) | MAPTRXFP1HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087456-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |