Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.65 |
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24359367 | 0.98 | HDAC1 (0.65) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL7996639 | 0.97 | HDAC1 (0.67) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL24359498 | 0.97 | HDAC1 (0.67) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL24359496 | 0.97 | HDAC1 (0.67) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL29516051 | 0.83 | ALDH1A1 (0.66) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL24359376 | 0.83 | ALDH1A1 (0.66) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL24359606 | 0.83 | HDAC1 (0.76) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL29516267 | 0.83 | HDAC1 (0.62) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL24359499 | 0.82 | HDAC1 (0.74) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL24359383 | 0.81 | HDAC1 (0.70) | HDAC1HDAC2HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087456-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |
| WO-2022087456-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |