Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9289349 | 0.83 | KMT2A (0.50) | CASP6KMT2AGRM5TGFBR1HSD17B13 | |
| SCHEMBL19589424 | 0.82 | MPO (0.46) | GABRA1GABRB2CASP6KMT2AGRM5 | |
| SCHEMBL17198955 | 0.78 | TYK2 (0.40) | KMT2AGRM5ADRA1DADRA1AADRA1B | |
| SCHEMBL16527783 | 0.76 | GABRA1 (0.76) | GABRA1GABRB2PTPN5ANPEPDPP4 | |
| SCHEMBL23108234 | 0.76 | ERN1 (0.44) | CASP6KMT2ATGFBR1ADRA1DADRA1A | |
| SCHEMBL24359769 | 0.75 | GABRA1 (0.47) | GABRA1GABRB2PTPN5ANPEPDPP4 | |
| SCHEMBL1095492 | 0.73 | KMT2A (0.55) | CASP6KMT2ATGFBR1ADRA1DADRA1A | |
| SCHEMBL30117290 | 0.72 | GABRA1 (0.61) | GABRA1GABRB2PTPN5ANPEPDPP4 | |
| Hydrochloric Acid SCHEMBL30549511 | 0.72 | KMT2A (0.53) | CASP6KMT2ATGFBR1ADRA1DADRA1A | |
| SCHEMBL28968048 | 0.72 | GABRA1 (0.61) | GABRA1GABRB2PTPN5ANPEPDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495358-B1 | AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2022-04-27 | — | — | EP | disclosed |