Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.54 |
| ▸ | MME | P08473 | 3/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.35 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.35 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bucillamine SCHEMBL930021 | 0.84 | MAPT (0.59) | ACEMMEACE2MAPTKDM4E | |
| Bucillamine SCHEMBL5060887 | 0.84 | MAPT (0.59) | ACEMMEACE2MAPTKDM4E | |
| Bucillamine SCHEMBL121965 | 0.84 | MAPT (0.59) | ACEMMEACE2MAPTKDM4E | |
| Bucillamine SCHEMBL522713 | 0.84 | MAPT (0.59) | ACEMMEACE2MAPTKDM4E | |
| SCHEMBL31406277 | 0.83 | POLB (0.40) | ACEMMEACE2MAPTKDM4E | |
| SCHEMBL19083738 | 0.83 | POLB (0.40) | ACEMMEACE2MAPTKDM4E | |
| SCHEMBL1349241 | 0.83 | POLB (0.40) | ACEMMEACE2MAPTKDM4E | |
| SCHEMBL929188 | 0.81 | ACE (0.51) | ACEMMEACE2MAPTKDM4E | |
| SCHEMBL24668413 | 0.81 | ALDH1A1 (0.58) | ACEMMEACE2MAPTFOLH1 | |
| SCHEMBL929192 | 0.81 | ACE (0.51) | ACEMMEACE2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022084747-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF OCULAR DISORDERS | Azura Ophthalmics Ltd. (IL) | 2022-04-28 | — | — | WO | disclosed |
| WO-2022084739-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF OCULAR DISORDERS | Azura Ophthalmics Ltd. (IL) | 2022-04-28 | — | — | WO | disclosed |
| WO-2022084738-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OF OCULAR DISORDERS | Azura Ophthalmics Ltd. (IL) | 2022-04-28 | — | — | WO | disclosed |