Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29632132 | 1.00 | IGF1R (0.43) | IGF1RMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL24360235 | 0.92 | IGF1R (0.39) | IGF1RMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL29521952 | 0.91 | GRM5 (0.44) | IGF1RMCHR1MCHR2 | |
| SCHEMBL25110220 | 0.91 | GRM5 (0.44) | IGF1RMCHR1MCHR2 | |
| SCHEMBL24360039 | 0.91 | IGF1R (0.46) | IGF1RMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL29632295 | 0.91 | IGF1R (0.46) | IGF1RMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL24494407 | 0.90 | MCHR1 (0.47) | IGF1RMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL29632199 | 0.90 | MCHR1 (0.47) | IGF1RMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL24360082 | 0.90 | MCHR1 (0.42) | IGF1RMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL24360253 | 0.90 | MCHR1 (0.46) | IGF1RMCHR1ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12384748-B2 | Modulators of mas-related g-protein receptor X2 and related products and methods | ESCIENT PHARMACEUTICALS, INC. (US) | 2025-08-12 | — | — | US | disclosed |
| US-20240351987-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS INC (US) | 2024-10-24 | — | — | US | disclosed |
| US-11970452-B2 | Modulators of mas-related G-protein receptor X2 and related products and methods | ESCIENT PHARMACEUTICALS, INC. (US) | 2024-04-30 | — | — | US | disclosed |
| EP-4232042-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-08-30 | — | — | EP | disclosed |
| US-20220177434-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. | 2022-06-09 | — | — | US | disclosed |
| US-20220177434-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. | 2022-06-09 | — | — | US | disclosed |
| WO-2022087083-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
| WO-2022087083-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220177434-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | MRGPRX2, MRGPRX1, MRGPRX4 | IGF1R 1173/4885MCHR1 34/4885ADRA2A 173/4885 |
| US-20240351987-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | MRGPRX2, MRGPRX1, MRGPRX4 | IGF1R 922/4885MCHR1 37/4885ADRA2A 133/4885 |
| US-11970452-B2 | Modulators of mas-related G-protein receptor X2 and related products and methods | MRGPRX2, MRGPRX1, MRGPRX4 | IGF1R 1173/4885MCHR1 34/4885ADRA2A 173/4885 |
| US-12384748-B2 | Modulators of mas-related g-protein receptor X2 and related products and methods | MRGPRX2, MRGPRX1, MRGPRX4 | IGF1R 922/4885MCHR1 37/4885ADRA2A 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.