Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 19/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439490 | 1.00 | GHSR (0.47) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2583398 | 0.85 | FAAH (0.48) | CCR5 | |
| SCHEMBL12299333 | 0.84 | SRD5A1 (0.42) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL12299329 | 0.84 | SRD5A1 (0.42) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2438384 | 0.84 | GHSR (0.46) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2438383 | 0.84 | GHSR (0.46) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL12299406 | 0.82 | GHSR (0.46) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2434584 | 0.81 | GHSR (0.68) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL12328248 | 0.81 | GHSR (0.47) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2435654 | 0.81 | GHSR (0.68) | GHSRCHRM2CYP3A4HTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547679-A1 | 2,3 DIHYDRO-1H-INDEN-1-YL- 2,7-DIAZASPIRO [3.6]NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | Pfizer Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011114271-A1 | 2,3 DIHYDRO-1H-INDEN-1-YL- 2,7-DIAZASPIRO [3.6] NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | PFIZER INC. (US) | 2011-09-22 | — | — | WO | disclosed |