Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | NUDT5 | Q9UKK9 | 3/20 | 0.48 |
| ▸ | TEC | P42680 | 1/20 | 0.48 |
| ▸ | BMX | P51813 | 1/20 | 0.48 |
| ▸ | CD69 | Q07108 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.48 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.48 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14241118 | 0.85 | NUDT14 (0.56) | BTKKCNH2EGFRNUDT5NUDT14 | |
| SCHEMBL24363242 | 0.84 | LCK (0.49) | BTKKCNH2EGFR | |
| SCHEMBL24363263 | 0.83 | TTBK1 (0.52) | BTKKCNH2EGFR | |
| SCHEMBL24363230 | 0.79 | BTK (0.69) | BTKKCNH2EGFRNUDT5TEC | |
| SCHEMBL24363496 | 0.78 | BTK (0.68) | BTKKCNH2EGFRNUDT5TEC | |
| SCHEMBL14165704 | 0.77 | BTK (0.70) | BTKKCNH2EGFRNUDT5TEC | |
| SCHEMBL20480850 | 0.77 | BTK (0.70) | BTKKCNH2EGFRNUDT5TEC | |
| SCHEMBL14165691 | 0.77 | BTK (0.70) | BTKKCNH2EGFRNUDT5TEC | |
| SCHEMBL18788360 | 0.77 | BTK (0.48) | BTKKCNH2EGFRNUDT5TEC | |
| SCHEMBL14165430 | 0.76 | BTK (0.66) | BTKKCNH2EGFRNUDT5TEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718270-B1 | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF PYRIMIDINE AND PYRIDINE COMPOUNDS WITH BTK INHIBITORY ACTIVITY | MERCK PATENT GMBH (DE) | 2022-04-27 | — | — | EP | disclosed |