Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.48 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 8/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.38 |
| ▸ | PIP5K1C | O60331 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30469738 | 1.00 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CBPIK3CGFTO | |
| SCHEMBL31136351 | 0.86 | SMN1; SMN2 (0.40) | ALDH1A1TP53SMN1; SMN2MAPTRAB9A | |
| SCHEMBL24363782 | 0.86 | SMN1; SMN2 (0.40) | ALDH1A1TP53SMN1; SMN2MAPTRAB9A | |
| SCHEMBL29981506 | 0.84 | LOXL2 (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGFTO | |
| SCHEMBL29980920 | 0.83 | AAK1 (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGFTO | |
| SCHEMBL24365876 | 0.82 | RAB9A (0.34) | ALDH1A1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL24364976 | 0.81 | HDAC6 (0.41) | — | |
| SCHEMBL32689015 | 0.81 | HDAC6 (0.41) | — | |
| SCHEMBL29081633 | 0.81 | HDAC6 (0.41) | — | |
| SCHEMBL29335687 | 0.81 | PDE3B (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-07-11 | — | — | US | disclosed |
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-07-11 | — | — | US | disclosed |
| CN-116568677-A | piperidin-1-yl-N-pyridin-3-yl-2-oxoacetamide derivatives useful for the treatment of MTAP deficiency and/or MTA accumulating cancers | 探戈医药股份有限公司 | 2023-08-08 | — | — | CN | disclosed |
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | PIK3CA 3586/4885PIK3CD 4481/4885PIK3CB 4586/4885 |
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | PIK3CA 3586/4885PIK3CD 4481/4885PIK3CB 4586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.