Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.72 |
| ▸ | CDK8 | P49336 | 2/20 | 0.72 |
| ▸ | CDK1 | P06493 | 1/20 | 0.72 |
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | SRC | P12931 | 7/20 | 0.52 |
| ▸ | ABL1 | P00519 | 8/20 | 0.52 |
| ▸ | BCR | P11274 | 3/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 2/20 | 0.44 |
| ▸ | STK25 | O00506 | 1/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2436643 | 0.93 | CDK8 (0.61) | CDK2CDK8CDK1KDRSRC | |
| SCHEMBL12972326 | 0.88 | CDK8 (0.74) | CDK2CDK8CDK1KDRSRC | |
| SCHEMBL12972266 | 0.87 | CDK8 (0.73) | CDK2CDK8CDK1KDRSRC | |
| SCHEMBL2435014 | 0.86 | KDR (0.52) | CDK2CDK8CDK1KDRLCK | |
| SCHEMBL29678277 | 0.84 | CDK2 (1.00) | CDK2CDK8CDK1KDRSRC | |
| SCHEMBL3676641 | 0.84 | CDK2 (1.00) | CDK2CDK8CDK1KDRSRC | |
| SCHEMBL12972324 | 0.83 | CDK8 (0.62) | CDK2CDK8CDK1KDRSRC | |
| SCHEMBL2779602 | 0.81 | CDK8 (0.63) | CDK2CDK8CDK1KDRSRC | |
| SCHEMBL2433982 | 0.80 | KDR (0.58) | KDRBRAFRETLCKMET | |
| SCHEMBL1324760 | 0.80 | CDK1 (0.72) | CDK2CDK8CDK1KDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |