Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.61 |
| ▸ | CDK2 | P24941 | 2/20 | 0.61 |
| ▸ | CDK1 | P06493 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 11/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 5/20 | 0.44 |
| ▸ | BCR | P11274 | 3/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | MET | P08581 | 4/20 | 0.43 |
| ▸ | TEK | Q02763 | 4/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 5/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2436659 | 0.93 | CDK2 (0.72) | CDK8CDK2CDK1KDRFGFR1 | |
| SCHEMBL12972324 | 0.88 | CDK8 (0.62) | CDK8CDK2CDK1KDRFGFR1 | |
| SCHEMBL2435014 | 0.86 | KDR (0.52) | CDK8CDK2CDK1KDRLCK | |
| SCHEMBL2433982 | 0.81 | KDR (0.58) | KDRLCKMETTEKFLT1 | |
| SCHEMBL12972326 | 0.80 | CDK8 (0.74) | CDK8CDK2CDK1KDRFGFR1 | |
| SCHEMBL12972266 | 0.80 | CDK8 (0.73) | CDK8CDK2CDK1KDRFGFR1 | |
| SCHEMBL10261435 | 0.79 | KDR (0.67) | KDRLCKMETTEK | |
| SCHEMBL2434370 | 0.79 | KDR (0.59) | CDK8CDK2CDK1KDRLCK | |
| SCHEMBL2435232 | 0.77 | KDR (0.54) | KDRLCKMETTEK | |
| SCHEMBL2434058 | 0.77 | KDR (0.53) | KDRLCKMETTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |