Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 6/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | DLK1 | P80370 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | ULK1 | O75385 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201885 | 0.84 | SYK (0.39) | SYKIRAK4MAPK1HPGDPDK2 | |
| SCHEMBL25839068 | 0.80 | MAPK1 (0.33) | SYKIRAK4MAP3K12MAPK1HSP90AB1 | |
| SCHEMBL25851514 | 0.77 | MAPK1 (0.37) | SYKIRAK4MAP3K12MAPK1HPGD | |
| SCHEMBL7950769 | 0.76 | MAPK1 (0.39) | SYKMAPK1HPGDPDK2PDK4 | |
| SCHEMBL13199608 | 0.73 | JAK2 (0.40) | SYKMAPK1HPGDHSP90AB1PDK2 | |
| SCHEMBL16946856 | 0.73 | MAPK1 (0.37) | SYKMAPK1HPGDPDK2PDK4 | |
| SCHEMBL14616216 | 0.73 | MAPK1 (0.62) | SYKMAPK1HPGDPDK2PDK4 | |
| SCHEMBL7454972 | 0.72 | HSD17B10 (0.35) | MAPK1HPGDHSD17B10ALDH1A1 | |
| SCHEMBL25839070 | 0.70 | SYK (0.37) | SYKMAPK1JAK2JAK1JAK3 | |
| SCHEMBL12253392 | 0.69 | MAPK1 (0.36) | SYKMAPK1HPGDHSD17B10PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087634-A1 | CTPS1 INHIBITORS AND USES THEREOF | NIMBUS CLOTHO, INC. (US) | 2022-04-28 | — | — | WO | disclosed |