Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 3/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | ULK1 | O75385 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201891 | 0.88 | MAPK1 (0.35) | MAPK1SYKJAK2JAK1JAK3 | |
| SCHEMBL24370189 | 0.80 | SYK (0.36) | MAPK1HSP90AB1SYKMAP3K12JAK2 | |
| SCHEMBL24126326 | 0.75 | IRAK4 (0.30) | IRAK4 | |
| SCHEMBL22201885 | 0.71 | SYK (0.39) | MAPK1SYKJAK2JAK1JAK3 | |
| SCHEMBL22822417 | 0.70 | SYK (0.49) | SYKJAK2JAK1JAK3 | |
| SCHEMBL18352331 | 0.68 | JAK2 (0.34) | MAPK1SYKJAK2JAK1JAK3 | |
| SCHEMBL19754801 | 0.68 | PRMT5 (0.41) | MAP3K12 | |
| SCHEMBL22822285 | 0.67 | MAPK1 (0.61) | MAPK1JAK3 | |
| SCHEMBL31229811 | 0.67 | CYP11B1 (0.35) | HSP90AB1 | |
| SCHEMBL20043290 | 0.67 | MET (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131122-A1 | FUSED RING-SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2023-07-13 | — | — | WO | disclosed |