Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 5/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7950769 | 0.77 | MAPK1 (0.39) | SYKMAPK1JAK2JAK1JAK3 | |
| SCHEMBL25851514 | 0.74 | MAPK1 (0.37) | SYKMAPK1JAK2JAK1JAK3 | |
| SCHEMBL14616216 | 0.74 | MAPK1 (0.62) | SYKMAPK1BRD4JAK2JAK1 | |
| SCHEMBL16946856 | 0.74 | MAPK1 (0.37) | SYKMAPK1JAK2JAK1JAK3 | |
| SCHEMBL13199608 | 0.74 | JAK2 (0.40) | SYKMAPK1JAK2JAK1JAK3 | |
| SCHEMBL10195822 | 0.73 | MAPK1 (0.50) | KITDYRK1AMAPK1BRD4AAK1 | |
| SCHEMBL22201885 | 0.71 | SYK (0.39) | SYKMAPK1JAK2JAK1JAK3 | |
| SCHEMBL24370189 | 0.70 | SYK (0.36) | SYKMAPK1JAK2JAK1JAK3 | |
| SCHEMBL12253392 | 0.70 | MAPK1 (0.36) | SYKCYP2C9MAPK1JAK2JAK1 | |
| SCHEMBL25839069 | 0.70 | LRRK2 (0.40) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131122-A1 | FUSED RING-SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2023-07-13 | — | — | WO | disclosed |