Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 5/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.39 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSH | P09668 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24370458 | 0.86 | CHRNB2 (0.47) | KDM5AHSD11B1EPHX2CYP2C9CHRNB2 | |
| SCHEMBL12515866 | 0.85 | HSD11B1 (0.57) | HSD11B1CYP2C9CTSKCA1CA2 | |
| SCHEMBL18820638 | 0.85 | HSD11B1 (0.57) | HSD11B1CYP2C9CTSKCA1CA2 | |
| SCHEMBL5746365 | 0.85 | HSD11B1 (0.57) | HSD11B1CYP2C9CTSKCA1CA2 | |
| SCHEMBL15691835 | 0.84 | KDM5A (0.47) | KDM5AHSD11B1CYP2C9 | |
| SCHEMBL10311742 | 0.83 | KDM5A (0.50) | KDM5AHSD11B1EPHX2CHRNB2CHRNA3 | |
| SCHEMBL29191203 | 0.81 | KDM5A (0.49) | KDM5AHSD11B1EPHX2CYP2C9CTSK | |
| SCHEMBL24371501 | 0.81 | KDM5A (0.49) | KDM5AHSD11B1EPHX2CYP2C9CTSK | |
| SCHEMBL22655447 | 0.81 | KDM5A (0.49) | KDM5AHSD11B1EPHX2CYP2C9CTSK | |
| SCHEMBL2908754 | 0.81 | KDM5A (0.49) | KDM5AHSD11B1EPHX2CYP2C9CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2023-11-28 | — | — | US | disclosed |
| WO-2022084741-A1 | CFTR MODULATOR COMPOUNDS, COMPOSITIONS, AND USES THEREOF | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | PDE4A, PDE4B, PDE5A | KDM5A 2589/4885HSD11B1 1395/4885EPHX2 1339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.