Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 12/20 | 0.53 |
| ▸ | SRC | P12931 | 4/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 3/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.53 |
| ▸ | FES | P07332 | 2/20 | 0.53 |
| ▸ | FER | P16591 | 2/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | MERTK | Q12866 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | CDK8 | P49336 | 2/20 | 0.53 |
| ▸ | STK25 | O00506 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434445 | 0.94 | HCK (0.54) | HCKSRCMKNK2ABL1MKNK1 | |
| SCHEMBL2434003 | 0.93 | HCK (0.55) | HCKSRCMKNK2ABL1MKNK1 | |
| SCHEMBL2434299 | 0.92 | SRC (0.51) | HCKSRCMKNK2ABL1MKNK1 | |
| SCHEMBL2434611 | 0.90 | KDR (0.53) | HCKSRCMKNK2ABL1MKNK1 | |
| SCHEMBL2435174 | 0.87 | HCK (0.56) | HCKSRCMKNK2ABL1MKNK1 | |
| SCHEMBL2435267 | 0.84 | CDK2 (0.58) | HCKSRCMKNK2ABL1MKNK1 | |
| SCHEMBL2433219 | 0.84 | KDR (0.54) | HCKSRCMKNK2ABL1MKNK1 | |
| SCHEMBL2435727 | 0.82 | KDR (0.56) | HCKSRCMKNK2ABL1MKNK1 | |
| SCHEMBL3309711 | 0.82 | CDK8 (0.62) | HCKSRCABL1MAP3K7MAP4K2 | |
| SCHEMBL2433730 | 0.80 | SRC (0.57) | HCKSRCMKNK2ABL1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110301157-A1 | BICYCLIC AMIDES AS KINASE INHIBITORS | NOVARTIS AG | 2011-12-08 | — | — | US | disclosed |
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301157-A1 | BICYCLIC AMIDES AS KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K19 | HCK 439/4885SRC 353/4885MKNK2 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.