Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 12/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.54 |
| ▸ | FLT3 | P36888 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.54 |
| ▸ | FES | P07332 | 2/20 | 0.54 |
| ▸ | FER | P16591 | 2/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | AXL | P30530 | 2/20 | 0.54 |
| ▸ | MERTK | Q12866 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | CDK8 | P49336 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | STK25 | O00506 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437272 | 0.94 | HCK (0.53) | HCKMKNK2FLT3SRCMKNK1 | |
| SCHEMBL2435174 | 0.93 | HCK (0.56) | HCKMKNK2FLT3SRCMKNK1 | |
| SCHEMBL2434299 | 0.91 | SRC (0.51) | HCKMKNK2FLT3SRCMKNK1 | |
| SCHEMBL2433219 | 0.90 | KDR (0.54) | HCKMKNK2FLT3SRCMKNK1 | |
| SCHEMBL2434003 | 0.87 | HCK (0.55) | HCKMKNK2FLT3SRCMKNK1 | |
| SCHEMBL2434611 | 0.84 | KDR (0.53) | HCKMKNK2FLT3SRCMKNK1 | |
| SCHEMBL2435267 | 0.84 | CDK2 (0.58) | HCKMKNK2FLT3SRCMKNK1 | |
| SCHEMBL2431862 | 0.82 | KDR (0.59) | FLT3MAPK14CSF1RPDGFRBKIT | |
| SCHEMBL30151207 | 0.82 | KDR (0.57) | HCKMKNK2FLT3SRCMKNK1 | |
| SCHEMBL2434456 | 0.82 | KDR (0.57) | HCKMKNK2FLT3SRCMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |