Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.51 |
| ▸ | ABL1 | P00519 | 6/20 | 0.51 |
| ▸ | HCK | P08631 | 6/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CDK8 | P49336 | 2/20 | 0.51 |
| ▸ | FES | P07332 | 2/20 | 0.51 |
| ▸ | FER | P16591 | 2/20 | 0.51 |
| ▸ | BCR | P11274 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.51 |
| ▸ | STK25 | O00506 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435267 | 0.92 | CDK2 (0.58) | SRCABL1HCKMKNK2MAP3K7 | |
| SCHEMBL2437272 | 0.92 | HCK (0.53) | SRCABL1HCKMKNK2MAP3K7 | |
| SCHEMBL2434445 | 0.91 | HCK (0.54) | SRCABL1HCKMKNK2MAP3K7 | |
| SCHEMBL4933283 | 0.85 | SRC (0.69) | SRCABL1HCKMKNK2MAP3K7 | |
| SCHEMBL2434003 | 0.84 | HCK (0.55) | SRCABL1HCKMKNK2MAP3K7 | |
| SCHEMBL2435174 | 0.84 | HCK (0.56) | SRCABL1HCKMKNK2MAP3K7 | |
| SCHEMBL2437280 | 0.82 | KDR (0.67) | SRCABL1HCKMKNK2MAP3K7 | |
| SCHEMBL2434611 | 0.81 | KDR (0.53) | SRCABL1HCKMKNK2MAP3K7 | |
| SCHEMBL2431407 | 0.81 | KDR (0.62) | KDRRAF1RETPDGFRBKIT | |
| SCHEMBL2433219 | 0.81 | KDR (0.54) | SRCABL1HCKMKNK2MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |