Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 10/20 | 0.43 |
| ▸ | HRH1 | P35367 | 10/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20317385 | 0.84 | ALDH1A1 (0.40) | HRH2HRH1SLC6A4ALDH1A1LMNA | |
| SCHEMBL20317530 | 0.84 | PIK3CD (0.44) | HRH2HRH1SLC6A4ALDH1A1LMNA | |
| SCHEMBL8404633 | 0.83 | HRH2 (0.45) | HRH2HRH1POLBRXFP1MTNR1B | |
| SCHEMBL19599560 | 0.83 | PAOX (0.42) | HRH2HRH1POLBHRH3SLC6A4 | |
| SCHEMBL21105813 | 0.81 | HSD11B1 (0.42) | HRH2HRH1SLC6A4MAPTSLC6A2 | |
| SCHEMBL21456135 | 0.81 | ALDH1A1 (0.40) | HRH2HRH1SLC6A4ALDH1A1GAA | |
| SCHEMBL21106222 | 0.80 | HRH1 (0.35) | HRH2HRH1SLC6A4SLC6A2HTR2A | |
| SCHEMBL19598467 | 0.80 | HRH1 (0.40) | HRH2HRH1SLC6A4ALDH1A1LMNA | |
| SCHEMBL4546642 | 0.78 | HSD11B1 (0.51) | HRH2HRH1POLBRXFP1MTNR1B | |
| SCHEMBL26801063 | 0.76 | HRH2 (0.44) | HRH2HRH1POLBRXFP1MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087216-A1 | DOUBLE DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |