Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19841676 | 0.86 | PTPN1 (0.52) | PTPN1POLBNPSR1L3MBTL1KDM4E | |
| SCHEMBL20988847 | 0.84 | PTPN1 (0.39) | PTPN1KDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4145613 | 0.82 | PTPN1 (0.55) | PTPN1POLBNPSR1L3MBTL1KDM4E | |
| SCHEMBL16643863 | 0.81 | PTPN1 (0.54) | PTPN1POLBNPSR1L3MBTL1KDM4E | |
| SCHEMBL19116660 | 0.81 | TDP1 (0.59) | PTPN1POLBNPSR1L3MBTL1KDM4E | |
| SCHEMBL22657559 | 0.80 | PTPN1 (0.56) | PTPN1POLBNPSR1L3MBTL1KDM4E | |
| SCHEMBL26997899 | 0.80 | PTPN1 (0.47) | PTPN1POLBNPSR1L3MBTL1KDM4E | |
| SCHEMBL12197944 | 0.78 | ALDH1A1 (0.60) | PTPN1POLBNPSR1L3MBTL1KDM4E | |
| SCHEMBL12932588 | 0.78 | POLB (0.53) | PTPN1POLBNPSR1L3MBTL1KDM4E | |
| SCHEMBL22434895 | 0.77 | POLB (0.70) | POLBNPSR1L3MBTL1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087216-A1 | DOUBLE DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |