Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.62 |
| ▸ | TNNI3K | Q59H18 | 16/20 | 0.62 |
| ▸ | BRAF | P15056 | 14/20 | 0.62 |
| ▸ | RAF1 | P04049 | 2/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2433093 | 0.92 | KDR (0.64) | KDRMAPK14TNNI3KBRAFRAF1 | |
| SCHEMBL4282402 | 0.89 | KDR (0.57) | KDRMAPK14TNNI3KBRAF | |
| SCHEMBL10261459 | 0.89 | KDR (0.52) | KDRMAPK14TNNI3KBRAF | |
| SCHEMBL2435957 | 0.89 | KDR (0.62) | KDRMAPK14TNNI3KBRAF | |
| SCHEMBL2437252 | 0.87 | RAF1 (0.53) | KDRMAPK14TNNI3KBRAFRAF1 | |
| SCHEMBL12972259 | 0.84 | KDR (0.62) | KDRMAPK14TNNI3KBRAFRAF1 | |
| SCHEMBL2433982 | 0.82 | KDR (0.58) | KDRMAPK14TNNI3KBRAF | |
| SCHEMBL2434322 | 0.81 | KDR (0.51) | KDRMAPK14TNNI3KBRAF | |
| SCHEMBL2708240 | 0.81 | KDR (0.48) | KDRTNNI3KRAF1 | |
| SCHEMBL12024426 | 0.81 | KDR (0.72) | KDRMAPK14TNNI3KBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |