Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 5/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 5/20 | 0.45 |
| ▸ | MET | P08581 | 4/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2709789 | 0.90 | KDR (0.50) | KDRTNNI3KMAP2K7RAF1 | |
| SCHEMBL2437154 | 0.86 | KDR (0.46) | KDRTNNI3KLCKMAP2K7MET | |
| SCHEMBL2706559 | 0.84 | KDR (0.46) | KDRLCKMETTEK | |
| SCHEMBL2778276 | 0.82 | KDR (0.51) | KDRTNNI3KMAP2K7RAF1 | |
| SCHEMBL2437401 | 0.81 | KDR (0.62) | KDRTNNI3KRAF1 | |
| SCHEMBL2780386 | 0.80 | KDR (0.49) | KDRTNNI3KMAP2K7RAF1 | |
| SCHEMBL2437252 | 0.80 | RAF1 (0.53) | KDRTNNI3KLCKMAP2K7MET | |
| SCHEMBL2778534 | 0.80 | KDR (0.48) | KDRTNNI3KMAP2K7RAF1 | |
| SCHEMBL2710189 | 0.75 | KDR (0.58) | KDRLCKMETTEK | |
| SCHEMBL2707692 | 0.75 | KDR (0.51) | KDRLCKMETTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110301157-A1 | BICYCLIC AMIDES AS KINASE INHIBITORS | NOVARTIS AG | 2011-12-08 | — | — | US | claimed |
| US-20120172386-A1 | Combinations Comprising a VEGF Receptor Inhibitor | NOVARTIS AG (CH) | 2012-07-05 | — | — | US | disclosed |
| EP-1945217-B1 | COMBINATIONS COMPRISING A VEGF RECEPTOR INHIBITOR AND A PENETRATION ENHANCER | NOVARTIS AG (CH) | 2012-05-02 | — | — | EP | disclosed |
| US-20110301157-A1 | BICYCLIC AMIDES AS KINASE INHIBITORS | NOVARTIS AG | 2011-12-08 | — | — | US | disclosed |
| US-20080306058-A1 | Combinations Comprising a Vegf Receptor Inhibitor | NOVARTIS AG | 2008-12-11 | — | — | US | disclosed |
| US-20080287427-A1 | Bicyclic Amides as Kinase Inhibitors | NOVARTIS AG (CH) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306058-A1 | Combinations Comprising a Vegf Receptor Inhibitor | KDR, FLT4, FLT1 | KDR 1/4885TNNI3K 1828/4885LCK 1705/4885 |
| US-20110301157-A1 | BICYCLIC AMIDES AS KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K19 | KDR 826/4885TNNI3K 111/4885LCK 275/4885 |
| US-20080287427-A1 | Bicyclic Amides as Kinase Inhibitors | MAP3K20, MAP3K1, MAP3K19 | KDR 888/4885TNNI3K 107/4885LCK 311/4885 |
| US-20120172386-A1 | Combinations Comprising a VEGF Receptor Inhibitor | KDR, FLT4, FLT1 | KDR 1/4885TNNI3K 1828/4885LCK 1705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.