Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 4/20 | 0.53 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 14/20 | 0.52 |
| ▸ | BRAF | P15056 | 5/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.51 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.51 |
| ▸ | MET | P08581 | 3/20 | 0.51 |
| ▸ | TEK | Q02763 | 3/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.51 |
| ▸ | FES | P07332 | 2/20 | 0.51 |
| ▸ | HCK | P08631 | 2/20 | 0.51 |
| ▸ | FER | P16591 | 2/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.51 |
| ▸ | STK25 | O00506 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435819 | 0.90 | KDR (0.53) | KDRBRAFMAPK14TNNI3KLCK | |
| SCHEMBL2437401 | 0.87 | KDR (0.62) | RAF1MAPK3KDRBRAFMAPK14 | |
| SCHEMBL2435014 | 0.83 | KDR (0.52) | KDRLCKMETTEKFLT1 | |
| SCHEMBL2435232 | 0.81 | KDR (0.54) | KDRLCKMETTEK | |
| SCHEMBL2432193 | 0.81 | KDR (0.56) | KDRBRAFMAPK14TNNI3KLCK | |
| SCHEMBL2434058 | 0.81 | KDR (0.53) | KDRLCKMETTEK | |
| SCHEMBL2708240 | 0.80 | KDR (0.48) | RAF1KDRTNNI3KLCKMET | |
| SCHEMBL22528892 | 0.79 | KDR (0.72) | RAF1MAPK3KDRBRAFMAPK14 | |
| SCHEMBL2433093 | 0.78 | KDR (0.64) | RAF1MAPK3KDRBRAFMAPK14 | |
| SCHEMBL4282402 | 0.76 | KDR (0.57) | KDRBRAFMAPK14MKNK2TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |