Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.57 |
| ▸ | FLT1 | P17948 | 3/20 | 0.57 |
| ▸ | FLT4 | P35916 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432193 | 0.92 | KDR (0.56) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2434309 | 0.91 | KDR (0.50) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2434370 | 0.86 | KDR (0.59) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2437406 | 0.86 | KDR (0.63) | KDRFLT1FLT4BRAFMAPK14 | |
| SCHEMBL2434130 | 0.84 | KDR (0.45) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2435819 | 0.83 | KDR (0.53) | KDRFLT1FLT4BRAFMAPK14 | |
| SCHEMBL2437298 | 0.78 | AR (0.41) | KDRBRAFCDK8 | |
| SCHEMBL2706761 | 0.78 | KDR (0.38) | KDRFLT1FLT4BRAFMAPK14 | |
| SCHEMBL2435957 | 0.78 | KDR (0.62) | KDRFLT1FLT4BRAFMAPK14 | |
| SCHEMBL2437389 | 0.78 | GRM4 (0.41) | CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |