Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 9/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.38 |
| ▸ | RICTOR | Q6R327 | 6/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.38 |
| ▸ | MAPKAP1 | Q9BPZ7 | 6/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 4/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30116128 | 0.77 | CHRNB2 (0.44) | CHRNB2CHRNA4MTORPIK3R1PIK3CA | |
| SCHEMBL15713541 | 0.76 | HDAC6 (0.39) | CHRNB2CHRNA4MTORPIK3R1PIK3CA | |
| SCHEMBL19897368 | 0.73 | CHRNB2 (0.43) | CHRNB2CHRNA4MTORPIK3R1PIK3CA | |
| SCHEMBL17651735 | 0.73 | CHRNB2 (0.43) | CHRNB2CHRNA4MTORPIK3R1PIK3CA | |
| SCHEMBL17108489 | 0.72 | MTOR (0.44) | CHRNB2CHRNA4MTORPIK3R1PIK3CA | |
| SCHEMBL17108491 | 0.72 | MTOR (0.44) | CHRNB2CHRNA4MTORPIK3R1PIK3CA | |
| SCHEMBL30316567 | 0.72 | MTOR (0.44) | CHRNB2CHRNA4MTORPIK3R1PIK3CA | |
| SCHEMBL30315969 | 0.72 | MTOR (0.44) | CHRNB2CHRNA4MTORPIK3R1PIK3CA | |
| SCHEMBL14916061 | 0.72 | CHRNB2 (0.43) | CHRNB2CHRNA4MTORPIK3R1PIK3CA | |
| SCHEMBL17796315 | 0.69 | MTOR (0.46) | CHRNB2CHRNA4MTORPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230043030-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2023-02-09 | — | — | US | disclosed |
| US-11478474-B2 | 2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-10-25 | — | — | US | disclosed |
| US-20220125785-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220125785-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | CYP3A4, CYP4B1, CYP3A5 | CHRNB2 3221/4885CHRNA4 949/4885MTOR 2836/4885 |
| US-11478474-B2 | 2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor | BTK, SYK, LCK | CHRNB2 4213/4885CHRNA4 4455/4885MTOR 128/4885 |
| US-20230043030-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | CYP3A43, CYP3A5, CYP11B2 | CHRNB2 2855/4885CHRNA4 3481/4885MTOR 2222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.