Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 9/20 | 0.67 |
| ▸ | MEN1 | O00255 | 9/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.67 |
| ▸ | RAB9A | P51151 | 8/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | PPARG | P37231 | 1/20 | 0.63 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.63 |
| ▸ | CRHBP | P24387 | 1/20 | 0.63 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12254392 | 0.90 | ALDH1A1 (0.68) | ALDH1A1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL2384899 | 0.89 | MEN1 (0.65) | ALDH1A1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL8743594 | 0.87 | ALDH1A1 (0.70) | ALDH1A1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL24375104 | 0.84 | ALDH1A1 (0.52) | ALDH1A1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL17703686 | 0.83 | MEN1 (0.71) | ALDH1A1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL10672530 | 0.83 | NPC1 (0.77) | ALDH1A1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL15419083 | 0.83 | L3MBTL1 (0.77) | ALDH1A1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL30227674 | 0.83 | NPC1 (0.77) | ALDH1A1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL10671477 | 0.82 | NPC1 (0.76) | ALDH1A1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL10671473 | 0.82 | NPC1 (0.76) | ALDH1A1NPC1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127271-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC SHP2 INHIBITOR COMPOUND, PREPARATION METHOD, AND USE | SHANGHAI RINGENE BIOPHARMA CO., LTD. (CN) | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127271-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC SHP2 INHIBITOR COMPOUND, PREPARATION METHOD, AND USE | PTPN1, PTPN7, PTPN9 | ALDH1A1 3157/4885NPC1 3718/4885MEN1 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.