Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 9/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.39 |
| ▸ | ATR | Q13535 | 4/20 | 0.39 |
| ▸ | ATRIP | Q8WXE1 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.38 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24375557 | 1.00 | IRAK4 (0.40) | IRAK4MTORPIK3C3PDCD1CD274 | |
| SCHEMBL24375904 | 0.81 | TACR3 (0.31) | — | |
| SCHEMBL24375505 | 0.80 | IRAK4 (0.31) | IRAK4 | |
| SCHEMBL13638968 | 0.79 | IRAK4 (0.50) | IRAK4MTORPIK3C3PIK3CAPIK3CD | |
| SCHEMBL24375507 | 0.73 | KMT2A (0.46) | — | |
| SCHEMBL24375495 | 0.71 | IRAK4 (0.41) | IRAK4MTORPIK3C3PDCD1CD274 | |
| SCHEMBL22838499 | 0.70 | MTOR (0.49) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL22838489 | 0.70 | MTOR (0.49) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL22838413 | 0.70 | MTOR (0.49) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL24175032 | 0.70 | ATR (0.48) | MTORPIK3C3PDCD1CD274CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3642199-B1 | BENZOFURANS AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2022-04-27 | — | — | EP | disclosed |