Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 7/20 | 0.40 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 6/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21889136 | 0.84 | LMNA (0.61) | IRAK4ATRATRIPCHEK1PDCD1 | |
| SCHEMBL24375533 | 0.84 | MTOR (0.44) | IRAK4ATRATRIPCHEK1PDCD1 | |
| SCHEMBL28003505 | 0.81 | ATR (0.46) | IRAK4ATRATRIPCHEK1PDCD1 | |
| SCHEMBL13634271 | 0.81 | IRAK4 (0.39) | IRAK4ATRATRIPCHEK1PDCD1 | |
| SCHEMBL28907413 | 0.80 | L3MBTL1 (0.40) | IRAK4ATRATRIPCHEK1PDCD1 | |
| SCHEMBL10278349 | 0.79 | IRAK4 (0.51) | IRAK4PIK3C3MTORPIK3CASMN1; SMN2 | |
| SCHEMBL20594891 | 0.79 | IRAK4 (0.51) | IRAK4PIK3C3MTORPIK3CASMN1; SMN2 | |
| SCHEMBL13162764 | 0.79 | MTOR (0.41) | IRAK4ATRPIK3C3PDE4DMTOR | |
| SCHEMBL3545517 | 0.78 | PDK1 (0.39) | LMNAL3MBTL1MTORPIK3CASMN1; SMN2 | |
| SCHEMBL3556057 | 0.76 | L3MBTL1 (0.46) | LMNAL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3642199-B1 | BENZOFURANS AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2022-04-27 | — | — | EP | disclosed |