Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | PDE8B | O95263 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1669217 | 0.88 | ERBB2 (0.39) | HSP90AA1HSP90AB1ERBB2PDE8BMAPT | |
| SCHEMBL1670392 | 0.83 | PDE2A (0.37) | HSP90AA1HSP90AB1CHRM4PDE8BMAPT | |
| SCHEMBL1670297 | 0.78 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1ERBB2 | |
| SCHEMBL1856028 | 0.75 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1ERBB2 | |
| SCHEMBL1860896 | 0.75 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1ERBB2 | |
| SCHEMBL1864346 | 0.75 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1ERBB2MAPT | |
| SCHEMBL1669717 | 0.75 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1CHRM4PDE8BRAB9A | |
| SCHEMBL1864503 | 0.73 | HSP90AB1 (0.52) | HSP90AA1HSP90AB1CHRM4RAB9A | |
| SCHEMBL24377240 | 0.72 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1ERBB2PDE8B | |
| SCHEMBL1672469 | 0.72 | PDE2A (0.38) | CHRM4PDE8BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694505-B1 | HSP90 INHIBITORS | SLOAN KETTERING INST CANCER RES (US) | 2022-04-27 | — | — | EP | disclosed |