Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9607407 | 0.87 | HRH3 (0.58) | KDM4EKMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL14240948 | 0.87 | HRH3 (0.56) | SMN1; SMN2MAPTOPRM1OPRD1OPRK1 | |
| SCHEMBL19362950 | 0.84 | PDE4B (0.58) | KDM4ENPC1RAB9APOLBKMT2A | |
| SCHEMBL9607063 | 0.83 | LMNA (0.53) | KDM4ELMNAMAPTOPRM1OPRD1 | |
| SCHEMBL29593315 | 0.83 | KDM4E (0.56) | KDM4ENPC1RAB9APOLBKMT2A | |
| SCHEMBL19778853 | 0.83 | KDM4E (0.56) | KDM4ENPC1RAB9APOLBKMT2A | |
| SCHEMBL21628634 | 0.83 | MAPT (0.57) | KDM4ENPC1RAB9APOLBKMT2A | |
| SCHEMBL13043807 | 0.82 | NNMT (0.61) | KDM4ENPC1RAB9APOLBKMT2A | |
| SCHEMBL6177649 | 0.81 | KDM4E (0.55) | KDM4ENPC1RAB9APOLBKMT2A | |
| SCHEMBL21656526 | 0.81 | LMNA (0.63) | KDM4ENPC1RAB9APOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484882-B1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | ZHEJIANG METON PHARMACEUTICAL CO LTD (CN) | 2022-04-27 | — | — | EP | disclosed |