Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.33 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29546431 | 1.00 | TDO2 (0.34) | TDO2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23726991 | 0.83 | CCNT1 (0.48) | TDO2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29952935 | 0.83 | CCNT1 (0.48) | TDO2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29830071 | 0.73 | GPR84 (0.40) | TDO2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29563361 | 0.73 | PIM1 (0.44) | TDO2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29563059 | 0.73 | PDE4A (0.40) | TDO2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL17971182 | 0.73 | PDE4A (0.40) | TDO2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29546657 | 0.73 | CCNT1 (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21055521 | 0.73 | CCNT1 (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL27030295 | 0.73 | GPR84 (0.40) | TDO2GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116249526-A | TYK2 selective inhibitors and uses thereof | 南京药石科技股份有限公司 | 2023-06-09 | — | — | CN | disclosed |
| WO-2022083560-A1 | TYK2 SELECTIVE INHIBITOR AND USE THEREOF | 南京药石科技股份有限公司 | 2022-04-28 | — | — | WO | disclosed |
| WO-2022083560-A1 | TYK2 SELECTIVE INHIBITOR AND USE THEREOF | 南京药石科技股份有限公司 | 2022-04-28 | — | — | WO | disclosed |