Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26938750 | 0.75 | SIRT3 (0.45) | KMT2AMEN1ATMSIRT1SIRT3 | |
| SCHEMBL29516215 | 0.74 | POLB (0.47) | KMT2ASMN1; SMN2MEN1HPGDPOLB | |
| SCHEMBL24378150 | 0.74 | POLB (0.47) | KMT2ASMN1; SMN2MEN1HPGDPOLB | |
| SCHEMBL29516400 | 0.74 | MAPK1 (0.54) | KMT2ASMN1; SMN2MEN1HPGDCHRM1 | |
| SCHEMBL24377989 | 0.74 | MAPK1 (0.54) | KMT2ASMN1; SMN2MEN1HPGDCHRM1 | |
| SCHEMBL24378022 | 0.73 | SIRT1 (0.55) | SIRT1SIRT3TDP1 | |
| SCHEMBL29516333 | 0.73 | SIRT1 (0.55) | SIRT1SIRT3TDP1 | |
| SCHEMBL24377997 | 0.73 | MAPT (0.50) | SMN1; SMN2CHRM1ALDH1A1RAB9AMAPT | |
| SCHEMBL11544729 | 0.66 | KMT2A (0.48) | KMT2ASMN1; SMN2MEN1HPGDSIRT1 | |
| SCHEMBL29516475 | 0.65 | KMT2A (0.49) | KMT2ASMN1; SMN2MEN1HPGDSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087433-A1 | COVALENT INHIBITORS OF CREATINE KINASE (CK) AND USES THEREOF FOR TREATING AND PREVENTING CANCER | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-04-28 | — | — | WO | disclosed |