Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 14/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.40 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24377969 | 0.89 | SIRT1 (0.50) | SIRT1SIRT3SIRT2DGAT1SOAT2 | |
| SCHEMBL24378019 | 0.81 | SIRT1 (0.48) | SIRT1SIRT3SIRT2POLB | |
| SCHEMBL26938751 | 0.79 | DGAT1 (0.40) | SIRT1DGAT1SOAT2CYP2C9SOAT1 | |
| SCHEMBL24378125 | 0.73 | SIRT1 (0.65) | SIRT1SIRT3SIRT2TDP1 | |
| SCHEMBL26938829 | 0.73 | SIRT1 (0.65) | SIRT1SIRT3SIRT2TDP1 | |
| SCHEMBL24378118 | 0.73 | SIRT1 (0.65) | SIRT1SIRT3SIRT2TDP1 | |
| SCHEMBL24377995 | 0.71 | SIRT1 (0.43) | SIRT1SIRT3SIRT2TDP1POLB | |
| SCHEMBL24378120 | 0.71 | SIRT1 (0.47) | SIRT1SIRT3SIRT2TDP1 | |
| SCHEMBL26938749 | 0.70 | POLB (0.44) | SIRT1CYP2C9POLB | |
| SCHEMBL24377971 | 0.68 | SIRT1 (0.43) | SIRT1SIRT3SIRT2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087433-A1 | COVALENT INHIBITORS OF CREATINE KINASE (CK) AND USES THEREOF FOR TREATING AND PREVENTING CANCER | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-04-28 | — | — | WO | disclosed |