Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 9/20 | 0.37 |
| ▸ | RAB9A | P51151 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468659 | 0.78 | ALDH1A1 (0.47) | MAPKAPK2ALDH1A1GAANPC1RAB9A | |
| Ammonia Solution, Strong SCHEMBL21070052 | 0.77 | ALDH1A1 (0.46) | MAPKAPK2ALDH1A1GAANPC1RAB9A | |
| SCHEMBL26351653 | 0.76 | KCNJ1 (0.50) | MAPKAPK2ALDH1A1GAANPC1RAB9A | |
| SCHEMBL6505228 | 0.76 | KDM4E (0.55) | ALDH1A1GAAPARP1PARP2PARP3 | |
| SCHEMBL6470229 | 0.76 | CA9 (0.47) | MAPKAPK2ALDH1A1GAAPARP1PARP2 | |
| SCHEMBL3568441 | 0.75 | ALDH1A1 (0.54) | ALDH1A1GAAPARP1PARP2PARP3 | |
| SCHEMBL21070649 | 0.73 | ALDH1A1 (0.40) | MAPKAPK2ALDH1A1GAAPARP1PARP2 | |
| SCHEMBL12800605 | 0.72 | RAB9A (0.55) | MAPKAPK2ALDH1A1GAAPARP1NPC1 | |
| SCHEMBL21070060 | 0.72 | MAPK1 (0.44) | MAPKAPK2ALDH1A1GAANPC1RAB9A | |
| SCHEMBL21069440 | 0.71 | NPC1 (0.43) | ALDH1A1GAAPARP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11318205-B1 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2022-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11318205-B1 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | MAPKAPK2 714/4885ALDH1A1 2776/4885GAA 1234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.