Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 11/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10077140 | 0.93 | CYP1A2 (0.34) | CYP1A2CYP2D6KMT2AMAPT | |
| SCHEMBL24034152 | 0.81 | CYP1A2 (0.34) | CYP1A2CYP2D6POLBSMN1; SMN2 | |
| SCHEMBL24034155 | 0.76 | POLB (0.39) | CYP1A2CYP2D6KMT2APOLBSMN1; SMN2 | |
| SCHEMBL30343506 | 0.74 | POLB (0.39) | CYP1A2CYP2D6KMT2APOLBSMN1; SMN2 | |
| Oxalic Acid SCHEMBL2438372 | 0.72 | DAGLA (0.39) | CYP1A2CYP2D6MAPTPOLBSMN1; SMN2 | |
| SCHEMBL4675449 | 0.72 | POLB (0.40) | CYP1A2CYP2D6KMT2AMAPTPOLB | |
| SCHEMBL16198654 | 0.71 | SMN1; SMN2 (0.36) | CYP1A2CYP2D6KMT2AMAPTPOLB | |
| SCHEMBL24034153 | 0.71 | POLB (0.32) | POLBSMN1; SMN2 | |
| SCHEMBL5603982 | 0.71 | CYP11B1 (0.30) | — | |
| SCHEMBL22615889 | 0.70 | KDM4E (0.31) | CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549873-A1 | NOVEL SPIRO IMIDAZOLONES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | Merck Sharp & Dohme Corp. (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119559-A1 | NOVEL SPIRO IMIDAZOLONES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | SCHERING CORPORATION (US) | 2011-09-29 | — | — | WO | disclosed |