Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24718850 | 0.86 | TLR7 (0.49) | TLR7TLR8 | |
| SCHEMBL22825827 | 0.78 | KCNH2 (0.41) | TLR7TLR8KCNH2 | |
| SCHEMBL22825626 | 0.78 | TLR7 (0.43) | TLR7TLR8KCNH2 | |
| SCHEMBL21325824 | 0.78 | TLR8 (0.64) | TLR7TLR8KCNH2 | |
| SCHEMBL24384575 | 0.78 | TLR8 (0.64) | TLR7TLR8KCNH2 | |
| SCHEMBL24719138 | 0.74 | KCNH2 (0.37) | TLR7TLR8KCNH2DHFR | |
| SCHEMBL15502359 | 0.72 | TLR7 (0.61) | TLR7TLR8 | |
| SCHEMBL24384694 | 0.71 | KCNH2 (0.42) | TLR7TLR8KCNH2DHFR | |
| SCHEMBL22825595 | 0.71 | KCNH2 (0.55) | TLR7TLR8KCNH2DHFR | |
| SCHEMBL22959000 | 0.71 | TLR7 (0.39) | TLR7TLR8KCNH2DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3759083-B1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF VIRUS INFECTIONS, CANCER OR ALLERGIES | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2022-05-04 | — | — | EP | disclosed |