Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22958960 | 0.79 | TLR8 (0.60) | KCNH2TLR8TLR7CYP2D6DRD1 | |
| SCHEMBL24384687 | 0.79 | TLR8 (0.60) | KCNH2TLR8TLR7CYP2D6DRD1 | |
| SCHEMBL22825827 | 0.76 | KCNH2 (0.41) | KCNH2TLR8TLR7CYP2D6DRD1 | |
| SCHEMBL22825626 | 0.76 | TLR7 (0.43) | KCNH2TLR8TLR7 | |
| SCHEMBL24718850 | 0.74 | TLR7 (0.49) | TLR8TLR7ALDH1A1 | |
| SCHEMBL24384574 | 0.74 | TLR7 (0.38) | KCNH2TLR8TLR7DHFR | |
| SCHEMBL22958959 | 0.72 | ALDH1A1 (0.33) | KCNH2TP53ALDH1A1HPGDMAPK1 | |
| SCHEMBL24384694 | 0.69 | KCNH2 (0.42) | KCNH2TLR8TLR7ALDH1A1CYP2D6 | |
| SCHEMBL22825595 | 0.67 | KCNH2 (0.55) | KCNH2TLR8TLR7ALDH1A1DHFR | |
| SCHEMBL24384683 | 0.66 | KCNH2 (0.50) | KCNH2TLR8TLR7CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4059924-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF | Janssen Sciences Ireland Unlimited Company (IE) | 2022-09-21 | — | — | EP | disclosed |