Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 2/20 | 0.65 |
| ▸ | CTSL | P07711 | 1/20 | 0.65 |
| ▸ | CTSS | P25774 | 1/20 | 0.65 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.65 |
| ▸ | TDP2 | O95551 | 3/20 | 0.60 |
| ▸ | NSD2 | O96028 | 3/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.60 |
| ▸ | CES1 | P23141 | 1/20 | 0.60 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | S100A4 | P26447 | 5/20 | 0.47 |
| ▸ | CDC25B | P30305 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18462344 | 0.93 | PTPRC (0.65) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL27346118 | 0.82 | TDP2 (0.50) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL27346577 | 0.82 | PTPRC (0.54) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL4048788 | 0.79 | PTPRC (1.00) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL30777768 | 0.79 | PTPRC (1.00) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL29419580 | 0.77 | TDP2 (1.00) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL460433 | 0.77 | TDP2 (1.00) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL9300812 | 0.76 | GAA (0.60) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL20089622 | 0.76 | GAA (0.60) | PTPRCCTSLCTSSPTPN13TDP2 | |
| SCHEMBL69772 | 0.75 | PTPRC (0.91) | PTPRCCTSLCTSSPTPN13TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954134-B1 | PROCESS FOR SYNTHESIZING A 2-PHENYL-1H-PHENANTRHO[9,10-D]IMIDAZOLE DERIVATIVE | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | disclosed |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | INCYTE CORPORATION | 2006-05-18 | — | — | US | disclosed |
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | PTPRC 50/4885CTSL 3608/4885CTSS 2859/4885 |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | JAK1, JAK2, JAK3 | PTPRC 50/4885CTSL 3608/4885CTSS 2859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.