Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.36 |
| ▸ | GABRP | O00591 | 3/20 | 0.36 |
| ▸ | GABRD | O14764 | 3/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.36 |
| ▸ | GABRE | P78334 | 3/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24342423 | 0.94 | ATR (0.38) | ATRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2435446 | 0.86 | ATR (0.49) | ATRP2RX3CA12CA1CA2 | |
| SCHEMBL18298896 | 0.84 | ATR (0.43) | ATRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL30726361 | 0.84 | ATR (0.43) | ATRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL17671029 | 0.83 | L3MBTL1 (0.40) | ATRGABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL4001036 | 0.83 | ATR (0.39) | ATRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL20850921 | 0.83 | ATR (0.39) | ATRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL28369496 | 0.82 | KDM4E (0.49) | ATRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL15712435 | 0.81 | ATR (0.38) | ATRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL15712602 | 0.81 | ATR (0.38) | ATRGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142509-B1 | QUINOLONES AND AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE | AMGEN INC (US) | 2013-12-04 | — | — | EP | disclosed |
| US-8349868-B2 | Azaquinolones that inhibit prolyl hydroxylase | AMGEN INC. (US) | 2013-01-08 | — | — | US | disclosed |
| EP-2097416-B1 | AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC (US) | 2012-09-12 | — | — | EP | disclosed |
| US-8048894-B2 | Quinolones and azaquinolones that inhibit prolyl hydroxylase | AMGEN INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-8048892-B2 | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof | AMGEN INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-20110224248-A1 | AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE | AMGEN INC. (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2142509-A2 | QUINOLONES AND AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE | Amgen, Inc (US) | 2010-01-13 | — | — | EP | disclosed |
| EP-2097416-A1 | AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | Amgen, Inc (US) | 2009-09-09 | — | — | EP | disclosed |
| US-20090156605-A1 | Quinolones and azaquinolones that inhbit prolyl hydroxylase | AMGEN INC. (US) | 2009-06-18 | — | — | US | disclosed |
| US-20090111806-A1 | Azaquinolone based compounds exhibiting prolyl hydroxylase Inhibitory activity, compositions, and uses thereof | AMGEN INC. (US) | 2009-04-30 | — | — | US | disclosed |
| WO-2008130600-A2 | QUINOLONES AND AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE | AMGEN INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008076425-A1 | AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156605-A1 | Quinolones and azaquinolones that inhbit prolyl hydroxylase | EGLN3, HIF1AN, EGLN2 | ATR 4472/4885GABRA1 1922/4885GABRG2 1569/4885 |
| US-20090111806-A1 | Azaquinolone based compounds exhibiting prolyl hydroxylase Inhibitory activity, compositions, and uses thereof | EGLN3, EGLN2, HIF1AN | ATR 3973/4885GABRA1 2205/4885GABRG2 1455/4885 |
| US-20110224248-A1 | AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE | HIF1AN, EGLN3, EGLN2 | ATR 4373/4885GABRA1 2028/4885GABRG2 1644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.