Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13996127 | 0.76 | AAK1 (0.42) | AAK1POLBNPSR1TDP1REN | |
| SCHEMBL13995754 | 0.74 | REN (0.46) | AAK1POLBNPSR1TDP1REN | |
| SCHEMBL18248093 | 0.72 | AAK1 (0.40) | AAK1REN | |
| SCHEMBL24323568 | 0.72 | AAK1 (0.40) | AAK1REN | |
| SCHEMBL8196748 | 0.72 | AAK1 (0.40) | AAK1REN | |
| SCHEMBL8079058 | 0.70 | AAK1 (0.42) | AAK1REN | |
| SCHEMBL22316960 | 0.70 | APLNR (0.31) | — | |
| SCHEMBL22315716 | 0.70 | APLNR (0.31) | — | |
| SCHEMBL25177947 | 0.69 | AAK1 (0.39) | AAK1REN | |
| SCHEMBL13999424 | 0.69 | AAK1 (0.39) | AAK1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022093856-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-05-05 | — | — | WO | disclosed |