Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924032 | 0.76 | TSHR (0.56) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL8819203 | 0.74 | TSHR (0.71) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL8820471 | 0.73 | TSHR (0.71) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL4886615 | 0.73 | LMNA (0.56) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL4894517 | 0.73 | SMN1; SMN2 (0.47) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL8819880 | 0.73 | TSHR (0.69) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL4892508 | 0.73 | SMN1; SMN2 (0.47) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL8109277 | 0.71 | TSHR (0.66) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL4895060 | 0.70 | TSHR (0.52) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL15127558 | 0.70 | TSHR (0.65) | TSHRLMNANPSR1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450362-B2 | Amidine-containing compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450362-B2 | Amidine-containing compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450362-B2 | Amidine-containing compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20120277250-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2012-11-01 | — | — | US | disclosed |
| US-20120277250-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2012-11-01 | — | — | US | disclosed |
| US-20120277250-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2012-11-01 | — | — | US | disclosed |
| US-8242138-B2 | Amidine-containing compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| US-8242138-B2 | Amidine-containing compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| US-8242138-B2 | Amidine-containing compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| US-20110294851-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110294851-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-8017617-B2 | Amidine-containing compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-8017617-B2 | Amidine-containing compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-8017617-B2 | Amidine-containing compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2011-09-13 | — | — | US | disclosed |
| EP-2222637-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20090170870-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE BIOPHARMA R&D IP, LLC | 2009-07-02 | — | — | US | disclosed |
| US-20090170870-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE BIOPHARMA R&D IP, LLC | 2009-07-02 | — | — | US | disclosed |
| US-20090170870-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE BIOPHARMA R&D IP, LLC | 2009-07-02 | — | — | US | disclosed |
| WO-2009079392-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009079392-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294851-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | CHRM3, CHRM5, CHRM1 | TSHR 132/4885LMNA 1918/4885NPSR1 166/4885 |
| US-20090170870-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | CHRM3, CHRM5, CHRM1 | TSHR 132/4885LMNA 1918/4885NPSR1 166/4885 |
| US-20120277250-A1 | AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | CHRM3, CHRM5, CHRM1 | TSHR 132/4885LMNA 1918/4885NPSR1 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.