Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | APAF1 | O14727 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8819203 | 0.98 | TSHR (0.71) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL8820471 | 0.84 | TSHR (0.71) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL8109277 | 0.84 | TSHR (0.66) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL15127558 | 0.83 | TSHR (0.65) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL8820679 | 0.82 | TSHR (0.62) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL3633383 | 0.80 | TSHR (0.61) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL8819191 | 0.79 | TSHR (0.59) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL8820492 | 0.79 | MAOA (0.48) | TSHRLMNANPSR1TP53ALDH1A1 | |
| SCHEMBL11483701 | 0.78 | TSHR (0.58) | TSHRLMNANPSR1TP53ALDH1A1 | |
| Xanthene Carboxylic Acid SCHEMBL2807858 | 0.78 | ATM (0.61) | TSHRLMNANPSR1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997046549-A1 | ANTI-NEURODEGENERATIVELY EFFECTIVE XANTHENE DERIVATIVES | NOVARTIS AG (CH) | 1997-12-11 | — | — | WO | claimed |
| WO-1997046549-A1 | ANTI-NEURODEGENERATIVELY EFFECTIVE XANTHENE DERIVATIVES | NOVARTIS AG (CH) | 1997-12-11 | — | — | WO | disclosed |