Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP4 | P49662 | 1/20 | 0.32 |
| ▸ | CASP5 | P51878 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1489984 | 0.98 | CHRM5 (0.46) | CHRM5ADRA2CACHECYP1A2SMN1; SMN2 | |
| SCHEMBL2439970 | 0.94 | CHRM5 (0.46) | CHRM5ADRA2CACHECYP1A2SMN1; SMN2 | |
| SCHEMBL713122 | 0.91 | CHRM5 (0.43) | CHRM5ADRA2C | |
| SCHEMBL39245 | 0.91 | CHRM5 (0.43) | CHRM5ADRA2C | |
| SCHEMBL3558127 | 0.85 | ADRA2C (0.50) | CHRM5ADRA2CACHECYP1A2SMN1; SMN2 | |
| SCHEMBL2444719 | 0.82 | GAA (0.35) | CHRM5ADRA2CCYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL3553234 | 0.82 | CHRM5 (0.46) | CHRM5ADRA2CACHELMNA | |
| SCHEMBL1489944 | 0.80 | CYP1A2 (0.47) | CHRM5ADRA2CCYP1A2ALDH1A1TP53 | |
| SCHEMBL161118 | 0.78 | CYP1A2 (0.44) | CHRM5ADRA2CCYP1A2TP53HRH3 | |
| SCHEMBL7114598 | 0.78 | ACHE (0.31) | CHRM5ADRA2CACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | disclosed |
| WO-2005000309-A2 | CHEMICAL COMPOUNDS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-01-06 | — | — | WO | disclosed |