Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.62 |
| ▸ | BTK | Q06187 | 16/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24388573 | 0.88 | JAK3 (0.62) | JAK3BTKMAP3K7MAPK1MAP2K1 | |
| SCHEMBL29537576 | 0.88 | EGFR (0.61) | JAK3BTKMAP3K7MAPK1MAP2K1 | |
| SCHEMBL29508118 | 0.88 | JAK3 (0.62) | JAK3BTKMAP3K7MAPK1MAP2K1 | |
| SCHEMBL24392850 | 0.88 | EGFR (0.61) | JAK3BTKMAP3K7MAPK1MAP2K1 | |
| Pebezertinib SCHEMBL24392854 | 0.86 | JAK3 (0.54) | JAK3BTKMAP3K7MAPK1MAP2K1 | |
| SCHEMBL29538046 | 0.84 | MAP3K7 (0.71) | JAK3BTKMAP3K7MAPK1MAP2K1 | |
| SCHEMBL24392701 | 0.84 | MAP3K7 (0.71) | JAK3BTKMAP3K7MAPK1MAP2K1 | |
| SCHEMBL24392805 | 0.84 | JAK3 (0.50) | JAK3BTKMAP3K7MAPK1MAP2K1 | |
| SCHEMBL24392761 | 0.83 | JAK3 (0.58) | JAK3BTKMAP3K7MAPK1MAP2K1 | |
| SCHEMBL29538322 | 0.83 | JAK3 (0.58) | JAK3BTKMAP3K7MAPK1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237418-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| CN-116685583-A | Pyrimidine compounds, compositions and pharmaceutical uses thereof | 缆图药品公司 | 2023-09-01 | — | — | CN | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |