Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21479425 | 0.87 | CNR2 (0.40) | CNR2ALDH1A1TSHRPSMD14CYP3A4 | |
| SCHEMBL8948376 | 0.83 | ALDH1A1 (0.62) | ALDH1A1TSHRPSMD14CYP3A4MAPK1 | |
| SCHEMBL20066465 | 0.80 | CNR2 (0.47) | CNR2ALDH1A1TSHRCNR1PSMD14 | |
| SCHEMBL10080950 | 0.80 | ALDH1A1 (0.60) | CNR2ALDH1A1TSHRCNR1PSMD14 | |
| SCHEMBL16173977 | 0.79 | TSHR (0.50) | CNR2ALDH1A1TSHRGFERMAPT | |
| SCHEMBL10152990 | 0.77 | CNR2 (0.45) | CNR2ALDH1A1TSHRCNR1PSMD14 | |
| SCHEMBL27560802 | 0.77 | ALDH1A1 (0.55) | ALDH1A1TSHRPSMD14CYP3A4MAPK1 | |
| SCHEMBL19121455 | 0.73 | ALDH1A1 (0.47) | CNR2ALDH1A1TSHRCNR1PSMD14 | |
| SCHEMBL12056655 | 0.72 | EGFR (0.46) | CNR2ALDH1A1TSHRCNR1PSMD14 | |
| SCHEMBL20037608 | 0.71 | KDM4E (0.33) | ALDH1A1PSMD14MAPK1GFERMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220133736-A1 | USES OF PYRIMIDOPYRIMIDINONES AS SIK INHIBITORS | THE GENERAL HOSPITAL CORPORATION (US) | 2022-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220133736-A1 | USES OF PYRIMIDOPYRIMIDINONES AS SIK INHIBITORS | SIK2, SIK1, SIK3 | CNR2 4783/4885ALDH1A1 1744/4885TSHR 4019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.