Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 7/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 9/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1009536 | 0.85 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10MGLLPPARA | |
| SCHEMBL1010961 | 0.85 | TAAR1 (0.53) | KDM4EALDH1A1HSD17B10NPSR1MGLL | |
| SCHEMBL2439261 | 0.85 | NPSR1 (0.39) | KDM4EALDH1A1HSD17B10NPSR1MGLL | |
| SCHEMBL4034715 | 0.83 | PPARA (0.54) | KDM4EALDH1A1HSD17B10NPSR1MGLL | |
| SCHEMBL2441914 | 0.82 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10NPSR1MGLL | |
| SCHEMBL4033438 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10NPSR1MGLL | |
| SCHEMBL5794671 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1HSD17B10MGLLPPARA | |
| SCHEMBL29224676 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10NPSR1MGLL | |
| SCHEMBL12895268 | 0.80 | GRIN2B (0.46) | MTNR1APPARG | |
| SCHEMBL5795204 | 0.78 | KDM4E (0.55) | KDM4EALDH1A1HSD17B10MGLLPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1433786-B1 | Benzoxazole compound and pharmaceutical composition containing the compound | KOWA CO (JP) | 2011-09-21 | — | — | EP | disclosed |
| EP-1433786-B1 | Benzoxazole compound and pharmaceutical composition containing the compound | KOWA CO (JP) | 2011-09-21 | — | — | EP | disclosed |
| EP-1433786-A1 | Benzoxazole compound and pharmaceutical composition containing the compound | Kowa Company Ltd. (JP) | 2004-06-30 | — | — | EP | disclosed |
| US-6653334-B1 | Electively activate peroxisome proliferator activated receptors | KOWA CO., LTD. (JP) | 2003-11-25 | — | — | US | disclosed |