Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 13/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033438 | 0.86 | KDM4E (0.53) | PPARAKDM4EALDH1A1HSD17B10MGLL | |
| SCHEMBL1010961 | 0.86 | TAAR1 (0.53) | PPARAKDM4EALDH1A1HSD17B10MGLL | |
| SCHEMBL29224676 | 0.85 | KDM4E (0.58) | PPARAKDM4EALDH1A1HSD17B10MGLL | |
| SCHEMBL2441914 | 0.83 | KDM4E (0.50) | PPARAKDM4EALDH1A1HSD17B10MGLL | |
| SCHEMBL2439441 | 0.83 | KDM4E (0.50) | PPARAKDM4EALDH1A1HSD17B10MGLL | |
| SCHEMBL5795204 | 0.82 | KDM4E (0.55) | PPARAKDM4EALDH1A1HSD17B10MGLL | |
| SCHEMBL5794671 | 0.82 | KDM4E (0.55) | PPARAKDM4EALDH1A1HSD17B10MGLL | |
| SCHEMBL3284352 | 0.82 | FBP1 (0.52) | PPARAPPARGCYP1A2CYP3A4 | |
| SCHEMBL8053756 | 0.81 | TAAR1 (0.40) | PPARAALDH1A1NPSR1MTNR1AMTNR1B | |
| SCHEMBL28489848 | 0.81 | KDM4E (0.48) | PPARAKDM4EALDH1A1HSD17B10MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049107-A2 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATION AND USES | Genfit (FR) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008012470-A2 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATION AND USES | GENFIT (FR) | 2008-01-31 | — | — | WO | disclosed |