Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 6/20 | 0.53 |
| ▸ | ABL1 | P00519 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480940 | 0.93 | TRPA1 (0.59) | TRPA1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL480411 | 0.93 | TRPA1 (0.58) | TRPA1ABL1CYP3A4MEN1KMT2A | |
| SCHEMBL15580544 | 0.89 | TRPA1 (0.50) | TRPA1ABL1MEN1KMT2ARAB9A | |
| SCHEMBL2453828 | 0.88 | ABL1 (0.48) | TRPA1ABL1MEN1KMT2ARAB9A | |
| SCHEMBL2440259 | 0.87 | TRPA1 (0.49) | TRPA1ABL1MEN1KMT2ARAB9A | |
| SCHEMBL480700 | 0.86 | TRPA1 (0.55) | TRPA1ABL1MEN1KMT2ARAB9A | |
| SCHEMBL2453157 | 0.86 | TRPA1 (0.48) | TRPA1ABL1MEN1KMT2ARAB9A | |
| SCHEMBL10171794 | 0.86 | TRPA1 (0.48) | TRPA1ABL1MEN1KMT2ARAB9A | |
| SCHEMBL480355 | 0.85 | TRPA1 (0.60) | TRPA1ABL1MEN1KMT2ARAB9A | |
| SCHEMBL2445209 | 0.84 | FFAR4 (0.50) | TRPA1ABL1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114184-A1 | AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114184-A1 | AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-22 | — | — | WO | disclosed |